CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (1)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin

PDB Structure

PDB 3GIC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Stabilization of the E* form turns thrombin into an anticoagulant.
Bah, A., Carrell, C.J., Chen, Z., Gandhi, P.S., Di Cera, E.
J.Biol.Chem.
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