CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.510 | Transferase(Phosphotransferase); domain 1 |
|
1.10.510.10 | Transferase(Phosphotransferase) domain 1 |
Domain Context
CATH Clusters
| Superfamily | Transferase(Phosphotransferase) domain 1 |
| Functional Family | Receptor protein serine/threonine kinase |
Enzyme Information
| 2.7.11.30 |
Receptor protein serine/threonine kinase.
based on mapping to UniProt Q13873
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 2.7.1.37.
|
UniProtKB Entries (1)
| Q13873 |
BMPR2_HUMAN
Homo sapiens
Bone morphogenetic protein receptor type-2
|
PDB Structure
| PDB | 3G2F |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural consequences of BMPR2 kinase domain mutations causing pulmonary arterial hypertension.
Sci Rep
|