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1 keywords

CATH Domain 3fqzA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.430 Dihydrofolate Reductase, subunit A
Homologous Superfamily 3.40.430.10 Dihydrofolate Reductase, subunit A

Domain Context

CATH Clusters

Superfamily Dihydrofolate Reductase, subunit A
Functional Family Dihydrofolate reductase

Enzyme Information

UniProtKB Entries (0)

PDB Structure

PDB 3FQZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance.
Frey, K.M., Liu, J., Lombardo, M.N., Bolstad, D.B., Wright, D.L., Anderson, A.C.
J.Mol.Biol.
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