CATH Domain 3fegA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1200	Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2
	3.90.1200.10	Aminoglycoside phosphotransferase (APH), C-terminal lobe

Domain Context

CATH Clusters

Superfamily	3.90.1200.10
Functional Family	Choline kinase alpha

Enzyme Information

2.7.1.82	Ethanolamine kinase. based on mapping to UniProt Q9Y259 ATP + ethanolamine = ADP + O-phosphoethanolamine.
2.7.1.32	Choline kinase. based on mapping to UniProt Q9Y259 ATP + choline = ADP + phosphocholine. -!- Ethanolamine and its methyl and ethyl derivatives can also act as acceptors.

UniProtKB Entries (1)

CHKB_HUMAN

Homo sapiens

Choline/ethanolamine kinase

PDB Structure

PDB	3FEG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity. Hong, B.S., Allali-Hassani, A., Tempel, W., Finerty, P.J., Mackenzie, F., Dimov, S., Vedadi, M., Park, H.W. J.Biol.Chem.