CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1220 | TPP-binding domain |
Domain Context
CATH Clusters
| Superfamily | TPP-binding domain |
| Functional Family | Pyruvate dehydrogenase [ubiquinone] |
Enzyme Information
| 1.2.5.1 |
Pyruvate dehydrogenase (quinone).
based on mapping to UniProt P07003
Pyruvate + ubiquinone + H(2)O = acetate + CO(2) + ubiquinol.
-!- This bacterial enzyme is located on the inner surface of the cytoplasmic membrane and coupled to the respiratory chain via ubiquinone. -!- Does not accept menaquinone. -!- Activity is greatly enhanced by lipids. -!- Requires thiamine diphosphate. -!- The enzyme can also form acetoin.
|
UniProtKB Entries (1)
| P07003 |
POXB_ECOLI
Escherichia coli K-12
Pyruvate dehydrogenase [ubiquinone]
|
PDB Structure
| PDB | 3EY9 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for membrane binding and catalytic activation of the peripheral membrane enzyme pyruvate oxidase from Escherichia coli.
Proc.Natl.Acad.Sci.USA
|
