CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.390 | Collagenase (Catalytic Domain) |
|
3.40.390.10 | Collagenase (Catalytic Domain) |
Domain Context
CATH Clusters
| Superfamily | Collagenase (Catalytic Domain) |
| Functional Family | Disintegrin and metalloproteinase domain-containing protein 17 |
Enzyme Information
| 3.4.24.86 |
ADAM 17 endopeptidase.
based on mapping to UniProt P78536
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val- Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha). Similarly cleaves other membrane-anchored, cell-surface proteins to 'shed' the extracellular domains.
-!- In vivo, the cleavage of tumor necrosis factor alpha precursor releases the soluble, 17-kDa TNF-alpha, which induces inflammation. -!- Belongs to peptidase family M12.
|
UniProtKB Entries (1)
| P78536 |
ADA17_HUMAN
Homo sapiens
Disintegrin and metalloproteinase domain-containing protein 17
|
PDB Structure
| PDB | 3EDZ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket.
Bioorg.Med.Chem.Lett.
|