CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.190 | Protein-Tyrosine Phosphatase; Chain A |
|
3.90.190.10 | Protein tyrosine phosphatase superfamily |
Domain Context
CATH Clusters
| Superfamily | Protein tyrosine phosphatase superfamily |
| Functional Family | Tyrosine-protein phosphatase non-receptor type 1 |
Enzyme Information
| 3.1.3.48 |
Protein-tyrosine-phosphatase.
based on mapping to UniProt P18031
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.
|
UniProtKB Entries (1)
| P18031 |
PTN1_HUMAN
Homo sapiens
Tyrosine-protein phosphatase non-receptor type 1
|
PDB Structure
| PDB | 3EAX |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors.
J.Am.Chem.Soc.
|
