CATH Domain 3dxjN06

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.274	Enzyme I; Chain A, domain 2
	1.10.274.100	RNA polymerase Rpb1, domain 3

Domain Context

CATH Clusters

Superfamily	RNA polymerase Rpb1, domain 3
Functional Family

Enzyme Information

2.7.7.6

DNA-directed RNA polymerase.

based on mapping to UniProt Q8RQE8

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

Q8RQE7

RPOZ_THET8

Thermus thermophilus HB8

DNA-directed RNA polymerase subunit omega

PDB Structure

PDB	3DXJ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The RNA polymerase "switch region" is a target for inhibitors. Mukhopadhyay, J., Das, K., Ismail, S., Koppstein, D., Jang, M., Hudson, B., Sarafianos, S., Tuske, S., Patel, J., Jansen, R., Irschik, H., Arnold, E., Ebright, R.H. Cell(Cambridge,Mass.)