CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | 2-hydroxy-3-oxopropionate reductase |
Enzyme Information
| 1.1.1.291 |
2-hydroxymethylglutarate dehydrogenase.
based on mapping to UniProt Q0QLF5
(S)-2-hydroxymethylglutarate + NAD(+) = 2-formylglutarate + NADH.
-!- NADP(+) cannot replace NAD(+). -!- Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. -!- Other enzymes involved in this pathway are EC 1.17.1.5, EC 1.3.7.1, EC 3.5.2.18, EC 5.4.99.4, EC 5.3.3.6, EC 4.2.1.85 and EC 4.1.3.32.
|
UniProtKB Entries (1)
| Q0QLF5 |
HMGD_EUBBA
Eubacterium barkeri
2-(hydroxymethyl)glutarate dehydrogenase
|
PDB Structure
| PDB | 3CKY |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural and Kinetic Properties of a beta-Hydroxyacid Dehydrogenase Involved in Nicotinate Fermentation.
J.Mol.Biol.
|
