CATH Domain 3cczB02

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.770	3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
	3.90.770.10	3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2

Superfamily	3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
Functional Family	3-hydroxy-3-methylglutaryl coenzyme A reductase

1.1.1.34

Hydroxymethylglutaryl-CoA reductase (NADPH).

based on mapping to UniProt P04035

(R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.

-!- The enzyme is inactivated by EC 2.7.11.31 and reactivated by EC 3.1.3.47.

HMDH_HUMAN

Homo sapiens

3-hydroxy-3-methylglutaryl-coenzyme A reductase

PDB	3CCZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase. Sarver, R.W., Bills, E., Bolton, G., Bratton, L.D., Caspers, N.L., Dunbar, J.B., Harris, M.S., Hutchings, R.H., Kennedy, R.M., Larsen, S.D., Pavlovsky, A., Pfefferkorn, J.A., Bainbridge, G. J.Med.Chem.