CATH Domain 3cajA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.200	Carbonic Anhydrase II
	3.10.200.10	Alpha carbonic anhydrase

Domain Context

CATH Clusters

Superfamily	Alpha carbonic anhydrase
Functional Family	Carbonic anhydrase 2

Enzyme Information

4.2.1.1

Carbonic anhydrase.

based on mapping to UniProt P00918

H(2)CO(3) = CO(2) + H(2)O.

-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

P00918

CAH2_HUMAN

Homo sapiens

Carbonic anhydrase 2

PDB Structure

PDB	3CAJ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors Di Fiore, A., Pedone, C., Antel, J., Waldeck, H., Witte, A., Wurl, M., Scozzafava, A., Supuran, C.T., De Simone, G. Bioorg.Med.Chem.Lett.