CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1820 | alpha/beta hydrolase |
Domain Context
CATH Clusters
| Superfamily | alpha/beta hydrolase |
| Functional Family | Protein phosphatase methylesterase 1 |
Enzyme Information
| 3.1.1.89 |
Protein phosphatase methylesterase-1.
based on mapping to UniProt Q9Y570
[Phosphatase 2A protein]-leucine methyl ester + H(2)O = [phosphatase 2A protein]-leucine + methanol.
-!- A key regulator of protein phosphatase 2A. -!- The methyl ester is formed by EC 2.1.1.233. -!- Occurs mainly in the nucleus.
|
UniProtKB Entries (1)
| Q9Y570 |
PPME1_HUMAN
Homo sapiens
Protein phosphatase methylesterase 1
|
PDB Structure
| PDB | 3C5V |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural mechanism of demethylation and inactivation of protein phosphatase 2A.
Cell(Cambridge,Mass.)
|
