CATH Domain 3bl9B02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.2240	mRNA decapping enzyme DcpS N-terminal fold
	3.30.2240.10	mRNA decapping enzyme DcpS N-terminal domain

Domain Context

CATH Clusters

Superfamily	mRNA decapping enzyme DcpS N-terminal domain
Functional Family

Enzyme Information

3.6.1.59

5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase.

based on mapping to UniProt Q96C86

A 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] + H(2)O = N(7)- methylguanosine 5'-phosphate + a 5'-diphospho-[mRNA].

-!- The enzyme removes (decaps) the N(7)-methylguanosine 5-phosphate cap from an mRNA degraded to a maximal length of 10 nucleotides. -!- Decapping is an important process in the control of eukaryotic mRNA degradation. -!- The enzyme functions to clear the cell of cap structure following decay of the RNA body. -!- The nematode enzyme can also decap triply methylated substrates, 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-[mRNA]. -!- Formerly EC 3.6.1.30.

UniProtKB Entries (1)

Q96C86

DCPS_HUMAN

Homo sapiens

M7GpppX diphosphatase

PDB Structure

PDB	3BL9
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	DcpS as a therapeutic target for spinal muscular atrophy. Singh, J., Salcius, M., Liu, S.W., Staker, B.L., Mishra, R., Thurmond, J., Michaud, G., Mattoon, D.R., Printen, J., Christensen, J., Bjornsson, J.M., Pollok, B.A., Kiledjian, M., Stewart, L., Jarecki, J., Gurney, M.E. Acs Chem.Biol.