CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
4 | Few Secondary Structures |
|
4.10 | Irregular |
|
4.10.140 | Epsilon-Thrombin; Chain L |
|
4.10.140.10 | Thrombin light chain domain |
Domain Context
CATH Clusters
| Superfamily | Thrombin light chain domain |
| Functional Family | Prothrombin |
Enzyme Information
| 3.4.21.5 |
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.
|
UniProtKB Entries (2)
| Q9N2I2 |
IPSP_BOVIN
Bos taurus
Plasma serine protease inhibitor
|
| P00734 |
THRB_HUMAN
Homo sapiens
Prothrombin
|
PDB Structure
| PDB | 3B9F |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex.
Proc.Natl.Acad.Sci.Usa
|
