CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.12780 | N-terminal domain of ligase-like |
Domain Context
CATH Clusters
| Superfamily | N-terminal domain of ligase-like |
| Functional Family | Acyl-coenzyme A synthetase ACSM2A, mitochondrial |
Enzyme Information
| 6.2.1.2 |
Medium-chain acyl-CoA ligase.
based on mapping to UniProt Q08AH3
ATP + a medium-chain fatty acid + CoA = AMP + diphosphate + a medium- chain acyl-CoA.
-!- Acts on fatty acids from C(4) to C(11) and on the corresponding 3-hydroxy and 2,3- or 3,4-unsaturated acids. -!- The enzyme from the bacterium Pseudomonas putida also acts on 4-oxo and 4-hydroxy derivatives.
|
UniProtKB Entries (1)
| Q08AH3 |
ACS2A_HUMAN
Homo sapiens
Acyl-coenzyme A synthetase ACSM2A, mitochondrial
|
PDB Structure
| PDB | 3B7W |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Trichoplusia |
| Primary Citation |
Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A.
J.Mol.Biol.
|
