CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.1280 | Alpha/beta knot |
|
3.40.1280.10 | SPOUT methyltransferase, trefoil knot domain |
Domain Context
CATH Clusters
| Superfamily | 3.40.1280.10 |
| Functional Family | tRNA (pseudouridine(54)-N(1))-methyltransferase |
Enzyme Information
| 2.1.1.257 |
tRNA (pseudouridine(54)-N(1))-methyltransferase.
based on mapping to UniProt Q59034
S-adenosyl-L-methionine + pseudouridine(54) in tRNA = S-adenosyl-L- homocysteine + N(1)-methylpseudouridine(54) in tRNA.
-!- While this archaeal enzyme is specific for the 54 position and does not methylate pseudouridine at position 55, the presence of pseudouridine at position 55 is necessary for the efficient methylation of pseudouridine at position 54.
|
UniProtKB Entries (1)
| Q59034 |
TRMY_METJA
Methanocaldococcus jannaschii DSM 2661
TRNA (pseudouridine(54)-N(1))-methyltransferase
|
PDB Structure
| PDB | 3AI9 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of Mj1640/DUF358 protein reveals a putative SPOUT-class RNA methyltransferase
J Mol Cell Biol
|