CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.300 | GMP Synthetase; Chain A, domain 3 |
|
3.30.300.110 | Met-10+ protein-like domains |
Domain Context
CATH Clusters
| Superfamily | Met-10+ protein-like domains |
| Functional Family | tRNA (guanine(37)-N1)-methyltransferase |
Enzyme Information
| 2.1.1.228 |
tRNA (guanine(37)-N(1))-methyltransferase.
based on mapping to UniProt Q58293
S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.
-!- This enzyme is important for the maintenance of the correct reading frame during translation. -!- Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. -!- Formerly EC 2.1.1.31.
|
UniProtKB Entries (1)
| Q58293 |
TRM5B_METJA
Methanocaldococcus jannaschii DSM 2661
TRNA (guanine(37)-N1)-methyltransferase Trm5b
|
PDB Structure
| PDB | 2ZZN |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Tertiary structure checkpoint at anticodon loop modification in tRNA functional maturation.
Nat.Struct.Mol.Biol.
|