CATH Domain 2yy8A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1280	Alpha/beta knot
	3.40.1280.10	SPOUT methyltransferase, trefoil knot domain

Domain Context

CATH Clusters

Superfamily	3.40.1280.10
Functional Family

Enzyme Information

2.1.1.206

tRNA (cytidine(56)-2'-O)-methyltransferase.

based on mapping to UniProt O58214

S-adenosyl-L-methionine + cytidine(56) in tRNA = S-adenosyl-L- homocysteine + 2'-O-methylcytidine(56) in tRNA.

-!- The archaeal enzyme specifically catalyzes the S-adenosyl-L- methionine dependent 2'-O-ribose methylation of cytidine at position 56 in tRNA transcripts.

UniProtKB Entries (1)

O58214

TRM56_PYRHO

Pyrococcus horikoshii OT3

TRNA (cytidine(56)-2'-O)-methyltransferase

PDB Structure

PDB	2YY8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure and mutational study of a unique SpoU family archaeal methylase that forms 2'-O-methylcytidine at position 56 of tRNA Kuratani, M., Bessho, Y., Nishimoto, M., Grosjean, H., Yokoyama, S. J.Mol.Biol.