CATH Domain 2yt2A00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.30	Roll
	2.30.29	PH-domain like
	2.30.29.30	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Domain Context

CATH Clusters

Superfamily	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Functional Family

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt Q9UM73

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

O43559

FRS3_HUMAN

Homo sapiens

Fibroblast growth factor receptor substrate 3

PDB Structure

PDB	2YT2
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	Structural basis for the recognition of nucleophosmin-anaplastic lymphoma kinase oncoprotein by the phosphotyrosine binding domain of Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target-2 Koshiba, S., Li, H., Motoda, Y., Tomizawa, T., Kasai, T., Tochio, N., Yabuki, T., Harada, T., Watanabe, S., Tanaka, A., Shirouzu, M., Kigawa, T., Yamamoto, T., Yokoyama, S. J.Struct.Funct.Genom.