CATH Domain 2xx3A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	Thymidylate kinase

Enzyme Information

2.7.4.9

dTMP kinase.

based on mapping to UniProt P23919

ATP + dTMP = ADP + dTDP.

UniProtKB Entries (1)

KTHY_HUMAN

Homo sapiens

Thymidylate kinase

PDB Structure

PDB	2XX3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Novel Antiviral C5-Substituted Pyrimidine Acyclic Nucleoside Phosphonates Selected as Human Thymidylate Kinase Substrates. Topalis, D., Pradere, U., Roy, V., Caillat, C., Azzouzi, A., Broggi, J., Snoeck, R., Andrei, G., Lin, J., Eriksson, S., Alexandre, J.A.C., El-Amri, C., Deville-Bonne, D., Meyer, P., Balzarini, J., Agrofoglio, L.A. J.Med.Chem.