CATH Domain 2xtjP01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.80	Peptidase S8 propeptide/proteinase inhibitor I9

Domain Context

CATH Clusters

Superfamily	Peptidase S8 propeptide/proteinase inhibitor I9
Functional Family	Proprotein convertase subtilisin/kexin type 9

Enzyme Information

3.4.21.-

Serine endopeptidases.

based on mapping to UniProt Q8NBP7

UniProtKB Entries (1)

PCSK9_HUMAN

Homo sapiens

Proprotein convertase subtilisin/kexin type 9

PDB Structure

PDB	2XTJ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A Pcsk9-Binding Antibody that Structurally Mimics the Egf(A) Domain of Ldl-Receptor Reduces Ldl Cholesterol in Vivo. Ni, Y.G., Di Marco, S., Condra, J.H., Peterson, L.B., Wang, W., Wang, F., Pandit, S., Hammond, H.A., Rosa, R., Cummings, R.T., Wood, D.D., Liu, X., Bottomley, M.J., Shen, X., Cubbon, R.M., Wang, S.P., Johns, D.G., Volpari, C., Hamuro, L., Chin, J., Huang, L., Zhao, J.Z., Vitelli, S., Haytko, P., Wisniewski, D., Mitnaul, L.J., Sparrow, C.P., Hubbard, B., Carfi, A., Sitlani, A. J.Lipid Res.