CATH Domain 2xszB01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	RuvB-like helicase

Enzyme Information

3.6.4.12

DNA helicase.

based on mapping to UniProt Q9Y265

ATP + H(2)O = ADP + phosphate.

-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

Q9Y230

RUVB2_HUMAN

Homo sapiens

RuvB-like 2

PDB Structure

PDB	2XSZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural and Functional Insights Into a Dodecameric Molecular Machine - the Ruvbl1/Ruvbl2 Complex. Gorynia, S., Bandeiras, T.M., Pinho, F.G., Mcvey, C.E., Vonrhein, C., Round, A., Svergun, D.I., Donner, P., Matias, P.M., Carrondo, M.A. J.Struct.Biol.