CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.190 | Protein-Tyrosine Phosphatase; Chain A |
|
3.90.190.20 | Mur ligase, C-terminal domain |
Domain Context
CATH Clusters
| Superfamily | Mur ligase, C-terminal domain |
| Functional Family | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase |
Enzyme Information
| 6.3.2.13 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase.
based on mapping to UniProt P9WJL3
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + meso-2,6- diaminoheptanedioate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L- alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate.
-!- Involved in the synthesis of a cell-wall peptide. -!- This enzyme adds diaminopimelate in Gram-negative organisms and in some Gram-positive organisms; in others EC 6.3.2.7 adds lysine instead. -!- It is the amino group of the L-center of the diaminopimelate that is acylated.
|
UniProtKB Entries (1)
| P9WJL3 |
MURE_MYCTU
Mycobacterium tuberculosis H37Rv
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
|
PDB Structure
| PDB | 2XJA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Essential Residues for the Enzyme Activity of ATP-Dependent Mure Ligase from Mycobacterium Tuberculosis.
Protein Cell
|