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CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.1260.70
Functional Family

Enzyme Information

2.7.7.n6
Guanine phosphate-protein transferase.
based on mapping to UniProt Q5ZSQ3
GTP + [protein]-L-tyrosine = diphosphate + [protein]-O(4)-(5'-guanylyl)- L-tyrosine.
-!- The enzyme from Legionella also functions as EC 2.7.7.n1.
2.7.7.n1
Protein adenylyltransferase.
based on mapping to UniProt Q5ZSQ3
(1) ATP + [protein]-L-tyrosine = diphosphate + [protein]-O(4)- (5'-adenylyl)-L-tyrosine. (2) ATP + [protein]-L-threonine = diphosphate + [protein]-O(4)- (5'-adenylyl)-L-threonine.

UniProtKB Entries (2)

Q5ZSQ3
DRRA_LEGPH
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Multifunctional virulence effector protein DrrA
P62820
RAB1A_HUMAN
Homo sapiens
Ras-related protein Rab-1A

PDB Structure

PDB 2WWX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Insights Into the Dual Nucleotide Exchange and Gdi Displacement Activity of Sidm/Drra
Suh, H.Y., Lee, D.W., Lee, K.H., Ku, B., Choi, S.J., Woo, J.S., Kim, Y.G., Oh, B.H.
Embo J.
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