CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.300 | GMP Synthetase; Chain A, domain 3 |
|
3.30.300.30 | ANL, C-terminal domain |
Domain Context
CATH Clusters
| Superfamily | 3.30.300.30 |
| Functional Family | Acyl-coenzyme A synthetase ACSM5, mitochondrial |
Enzyme Information
| 6.2.1.2 |
Medium-chain acyl-CoA ligase.
based on mapping to UniProt Q08AH3
ATP + a medium-chain fatty acid + CoA = AMP + diphosphate + a medium- chain acyl-CoA.
-!- Acts on fatty acids from C(4) to C(11) and on the corresponding 3-hydroxy and 2,3- or 3,4-unsaturated acids. -!- The enzyme from the bacterium Pseudomonas putida also acts on 4-oxo and 4-hydroxy derivatives.
|
UniProtKB Entries (1)
| Q08AH3 |
ACS2A_HUMAN
Homo sapiens
Acyl-coenzyme A synthetase ACSM2A, mitochondrial
|
PDB Structure
| PDB | 2WD9 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Snapshots for the Conformation- Dependent Catalysis by Human Medium-Chain Acyl- Coenzyme a Synthetase Acsm2A.
J.Mol.Biol.
|
