CATH Domain 2vfxG00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.900	Cell Cycle, Spindle Assembly Checkpoint Protein; Chain A
	3.30.900.10	HORMA domain

Domain Context

CATH Clusters

Superfamily	HORMA domain
Functional Family	Mitotic spindle assembly checkpoint protein MAD2A

Enzyme Information

UniProtKB Entries (1)

MD2L1_HUMAN

Homo sapiens

Mitotic spindle assembly checkpoint protein MAD2A

PDB Structure

PDB	2VFX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Insights Into MAD2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric MAD2 Dimer. Yang, M., Li, B., Liu, C.-J., Tomchick, D.R., Machius, M., Rizo, J., Yu, H., Luo, X. Plos Biol.