CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.70 | Alpha-Beta Plaits |
|
3.30.70.2510 |
Domain Context
CATH Clusters
| Superfamily | 3.30.70.2510 |
| Functional Family | tRNA pseudouridine synthase Pus10 |
Enzyme Information
| 5.4.99.25 |
tRNA pseudouridine(55) synthase.
based on mapping to UniProt Q3MIT2
tRNA uridine(55) = tRNA pseudouridine(55).
-!- Pseudourine synthase TruB from Escherichia coli specifically modifies uridine(55) in tRNA molecules. -!- The bifunctional archaeal enzyme also catalyzes the pseudouridylation of uridine(54). -!- It is not known whether the enzyme from Escherichia coli can also act on position 54 in vitro, since this position is occupied in E.coli tRNAs by thymine.
|
UniProtKB Entries (1)
| Q3MIT2 |
PUS10_HUMAN
Homo sapiens
Putative tRNA pseudouridine synthase Pus10
|
PDB Structure
| PDB | 2V9K |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure of Human Pus10, a Novel Pseudouridine Synthase.
J.Mol.Biol.
|
