CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.310 | TATA-Binding Protein |
|
3.30.310.80 | Kinase associated domain 1, KA1 |
Domain Context
CATH Clusters
| Superfamily | Kinase associated domain 1, KA1 |
| Functional Family | Non-specific serine/threonine protein kinase |
Enzyme Information
| 2.7.11.26 |
[Tau protein] kinase.
based on mapping to UniProt P54645
ATP + [tau protein] = ADP + [tau protein] phosphate.
-!- Activated by tubulin. -!- Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease. -!- Formerly EC 2.7.1.135.
|
| 2.7.11.31 |
[Hydroxymethylglutaryl-CoA reductase (NADPH)] kinase.
based on mapping to UniProt P54645
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate.
-!- Activated by AMP. -!- EC 1.1.1.34 is inactivated by the phosphorylation of the enzyme protein. -!- Histones can also act as acceptors. -!- Can also phosphorylate EC 6.4.1.2 and EC 3.1.1.79. -!- Thr-172 within the catalytic subunit (alpha-subunit) is the major site phosphorylated by the AMP-activated protein kinase kinase. -!- GTP can act instead of ATP. -!- Formerly EC 2.7.1.109.
|
| 2.7.11.27 |
[Acetyl-CoA carboxylase] kinase.
based on mapping to UniProt P54645
ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate.
-!- Phosphorylates and inactivates EC 6.4.1.2, which can be dephosphorylated and reactivated by EC 3.1.3.17. -!- More active toward the dimeric form of acetyl-CoA carboxylase than the polymeric form. -!- Phosphorylates serine residues. -!- Formerly EC 2.7.1.111 and EC 2.7.1.128.
|
| 2.7.11.1 |
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P54645
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
|
UniProtKB Entries (2)
| P54645 |
AAPK1_RAT
Rattus norvegicus
5'-AMP-activated protein kinase catalytic subunit alpha-1
|
| O43741 |
AAKB2_HUMAN
Homo sapiens
5'-AMP-activated protein kinase subunit beta-2
|
PDB Structure
| PDB | 2V8Q |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Basis for AMP Binding to Mammalian AMP-Activated Protein Kinase
Nature
|