CATH Domain 2uzyD02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1680	ligand-binding face of the semaphorins, domain 2
	3.30.1680.10	ligand-binding face of the semaphorins, domain 2

Domain Context

CATH Clusters

Superfamily	ligand-binding face of the semaphorins, domain 2
Functional Family

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P08581

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (2)

P0DQD2	INLB_LISMO Listeria monocytogenes EGD-e Internalin B
P08581	MET_HUMAN Homo sapiens Hepatocyte growth factor receptor

PDB Structure

PDB	2UZY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of the Human Receptor Tyrosine Kinase met in Complex with the Listeria Invasion Protein Inlb Niemann, H.H., Jager, V., Butler, P.J.G., van den Heuvel, J., Schmidt, S., Ferraris, D., Gherardi, E., Heinz, D.W. Cell(Cambridge,Mass.)