CATH Classification

Domain Context

CATH Clusters

Superfamily 6.10.250.2970
Functional Family

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt Q5ZXE0
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q5ZXE0
MIP_LEGPH
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Outer membrane protein MIP

PDB Structure

PDB 2UZ5
External Links
Method SOLUTION NMR
Organism
Primary Citation
Domain Motions of the Mip Protein from Legionella Pneumophila
Horstmann, M., Ehses, P., Schweimer, K., Steinert, M., Kamphausen, T., Fischer, G., Hacker, J., Rosch, P., Faber, C.
Biochemistry