CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.572 | Thymidylate Synthase; Chain A |
|
3.30.572.10 | Thymidylate synthase/dCMP hydroxymethylase domain |
Domain Context
CATH Clusters
| Superfamily | Thymidylate synthase/dCMP hydroxymethylase domain |
| Functional Family | Possible thymidylate synthase |
Enzyme Information
| 2.1.1.45 |
Thymidylate synthase.
based on mapping to UniProt P04818
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
|
UniProtKB Entries (1)
| P04818 |
TYSY_HUMAN
Homo sapiens
Thymidylate synthase
|
PDB Structure
| PDB | 2RDA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The R163K mutant of human thymidylate synthase is stabilized in an active conformation: structural asymmetry and reactivity of cysteine 195.
Biochemistry
|