CATH Domain 2r4fD02

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.770	3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
	3.90.770.10	3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2

Superfamily	3-hydroxy-3-methylglutaryl-coenzyme A Reductase; Chain A, domain 2
Functional Family	3-hydroxy-3-methylglutaryl coenzyme A reductase

1.1.1.34

Hydroxymethylglutaryl-CoA reductase (NADPH).

based on mapping to UniProt P04035

(R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.

-!- The enzyme is inactivated by EC 2.7.11.31 and reactivated by EC 3.1.3.47.

HMDH_HUMAN

Homo sapiens

3-hydroxy-3-methylglutaryl-coenzyme A reductase

PDB	2R4F
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hypercholesterolemia. Pfefferkorn, J.A., Choi, C., Larsen, S.D., Auerbach, B., Hutchings, R., Park, W., Askew, V., Dillon, L., Hanselman, J.C., Lin, Z., Lu, G.H., Robertson, A., Sekerke, C., Harris, M.S., Pavlovsky, A., Bainbridge, G., Caspers, N., Kowala, M., Tait, B.D. J.Med.Chem.