CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.620 | HUPs |
Domain Context
CATH Clusters
| Superfamily | HUPs |
| Functional Family | Tryptophan--tRNA ligase, cytoplasmic |
Enzyme Information
| 6.1.1.2 |
Tryptophan--tRNA ligase.
based on mapping to UniProt P23381
ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl- tRNA(Trp).
|
UniProtKB Entries (1)
| P23381 |
SYWC_HUMAN
Homo sapiens
Tryptophan--tRNA ligase, cytoplasmic
|
PDB Structure
| PDB | 2QUK |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Catalytic mechanism of the tryptophan activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states
Nucleic Acids Res.
|
