CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.80 | Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module |
Domain Context
CATH Clusters
| Superfamily | Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module |
| Functional Family | NADPH--cytochrome P450 reductase |
Enzyme Information
| 1.16.1.8 |
[Methionine synthase] reductase.
based on mapping to UniProt Q9UBK8
2 [methionine synthase]-methylcob(III)alamin + 2 S-adenosylhomocysteine + NADP(+) = 2 [methionine synthase]-cob(II)alamin + NADPH + 2 S-adenosyl-L- methionine.
-!- The substrate of the enzyme is the inactivated cobalt(II) form of EC 2.1.1.13. -!- Electrons are transferred from NADPH to FAD to FMN. -!- Formerly EC 2.1.1.135.
|
UniProtKB Entries (1)
| Q9UBK8 |
MTRR_HUMAN
Homo sapiens
Methionine synthase reductase
|
PDB Structure
| PDB | 2QTL |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Mechanism of Coenzyme Binding to Human Methionine Synthase Reductase Revealed through the Crystal Structure of the FNR-like Module and Isothermal Titration Calorimetry
Biochemistry
|