CATH Domain 2qfbI00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.170	Beta Complex
	2.170.150	Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A
	2.170.150.30	RIG-I-like receptor, C-terminal regulatory domain

Domain Context

CATH Clusters

Superfamily	RIG-I-like receptor, C-terminal regulatory domain
Functional Family	Probable ATP-dependent RNA helicase DDX58

Enzyme Information

3.6.4.13

RNA helicase.

based on mapping to UniProt O95786

ATP + H(2)O = ADP + phosphate.

-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

O95786

DDX58_HUMAN

Homo sapiens

Probable ATP-dependent RNA helicase DDX58

PDB Structure

PDB	2QFB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The C-Terminal Regulatory Domain Is the RNA 5'-Triphosphate Sensor of RIG-I. Cui, S., Eisenacher, K., Kirchhofer, A., Brzozka, K., Lammens, A., Lammens, K., Fujita, T., Conzelmann, K.K., Krug, A., Hopfner, K.P. Mol.Cell