CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family | Uridine monophosphate synthetase |
Enzyme Information
| 2.4.2.10 |
Orotate phosphoribosyltransferase.
based on mapping to UniProt P11172
Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- The enzyme from higher eukaryotes also catalyzes the reaction listed as EC 4.1.1.23.
|
| 4.1.1.23 |
Orotidine-5'-phosphate decarboxylase.
based on mapping to UniProt P11172
Orotidine 5'-phosphate = UMP + CO(2).
-!- The enzyme from higher eukaryotes is identical with EC 2.4.2.10.
|
UniProtKB Entries (1)
| P11172 |
UMPS_HUMAN
Homo sapiens
Uridine 5'-monophosphate synthase
|
PDB Structure
| PDB | 2QCE |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design.
Structure
|
