CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.11370 |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.11370 |
| Functional Family |
Enzyme Information
| 2.7.1.134 |
Inositol-tetrakisphosphate 1-kinase.
based on mapping to UniProt Q13572
ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.
-!- This enzyme also phosphorylates Ins(1,3,4)P(3) on O-5 and O-6. -!- The phosphotransfer from ATP to either inositol 1,3,4-trisphosphate or inositol 3,4,5,6-tetrakisphosphate appears to be freely reversible to the extent that the enzyme can act like an inositol polyphosphate phosphatase in the presence of ADP. -!- It can also catalyze an isomerization between Ins(1,3,4,5)P(4) and Ins(1,3,4,6)P(4) in the presence of ADP. -!- Formerly EC 2.7.1.133 and EC 2.7.1.139.
|
| 2.7.1.159 |
Inositol-1,3,4-trisphosphate 5/6-kinase.
based on mapping to UniProt Q13572
(1) ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate. (2) ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate.
-!- In humans, this enzyme, along with EC 2.7.1.127, EC 2.7.1.140 and EC 2.7.1.158 is involved in the production of inositol hexakisphosphate (InsP(6)). -!- InsP(6) is involved in many cellular processes, including mRNA export from the nucleus. -!- Yeast do not have this enzyme, so produce InsP(6) from Ins(1,4,5)P(3) by the actions of EC 2.7.1.151 and EC 2.7.1.158.
|
UniProtKB Entries (1)
| Q13572 |
ITPK1_HUMAN
Homo sapiens
Inositol-tetrakisphosphate 1-kinase
|
PDB Structure
| PDB | 2QB5 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Integration of inositol phosphate signaling pathways via human ITPK1.
J.Biol.Chem.
|