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1 keywords

CATH Domain 2pk5A00

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.40 Beta Barrel
Topology 2.40.70 Cathepsin D, subunit A; domain 1
Homologous Superfamily 2.40.70.10 Acid Proteases

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Gag-Pol polyprotein

Enzyme Information

UniProtKB Entries (1)

Q9J2P7
Q9J2P7_9HIV1
Human immunodeficiency virus 1
Protease

PDB Structure

PDB 2PK5
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Compensating enthalpic and entropic changes hinder binding affinity optimization.
Lafont, V., Armstrong, A.A., Ohtaka, H., Kiso, Y., Mario Amzel, L., Freire, E.
Chem.Biol.Drug Des.
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