CATH Domain 2phkA02

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	phosphorylase b kinase gamma catalytic chain, liver/testis isoform

Enzyme Information

2.7.11.1	Non-specific serine/threonine protein kinase. based on mapping to UniProt P00518 ATP + a protein = ADP + a phosphoprotein. -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
2.7.11.26	[Tau protein] kinase. based on mapping to UniProt P00518 ATP + [tau protein] = ADP + [tau protein] phosphate. -!- Activated by tubulin. -!- Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease. -!- Formerly EC 2.7.1.135.
2.7.11.19	Phosphorylase kinase. based on mapping to UniProt P00518 2 ATP + phosphorylase b = 2 ADP + phosphorylase a. -!- Requires calmodulin for activity. -!- The enzyme phosphorylates a specific serine residue in each of the subunits of the dimeric phosphorylase b. -!- For muscle phosphorylase but not liver phosphorylase, this is accompanied by a further dimerization to form a tetrameric phosphorylase. -!- The enzyme couples muscle contraction with energy production via glycogenolysis--glycolysis by catalyzing the Ca(2+)-dependent phosphorylation and activation of glycogen phosphorylase b. -!- The gamma subunit of the tetrameric alpha-beta-gamma-delta enzyme is the catalytic subunit. -!- Formerly EC 2.7.1.38.

UniProtKB Entries (1)

PHKG1_RABIT

Oryctolagus cuniculus

Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform

PDB Structure

PDB	2PHK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition. Lowe, E.D., Noble, M.E., Skamnaki, V.T., Oikonomakos, N.G., Owen, D.J., Johnson, L.N. EMBO J.