CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.30 | Roll | |
2.30.140 | Spermidine Synthase; Chain: A, domain 2 | |
2.30.140.10 | Spermidine synthase, tetramerisation domain |
Domain Context
CATH Clusters
Superfamily | Spermidine synthase, tetramerisation domain |
Functional Family | SPE3p Spermidine synthase |
Enzyme Information
2.5.1.16 |
Spermidine synthase.
based on mapping to UniProt P19623
S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl- 5'-thioadenosine + spermidine.
-!- The enzymes from the plant Glycine max and from mammalia are highly specific for putrescine as the amine acceptor. -!- The enzymes from the bacteria Escherichia coli and Thermotoga maritima prefer putrescine but are more tolerant toward other amine acceptors, such as spermidine and cadaverine. -!- Cf. EC 2.5.1.22 and EC 2.5.1.23.
|
UniProtKB Entries (1)
P19623 |
SPEE_HUMAN
Homo sapiens
Spermidine synthase
|
PDB Structure
PDB | 2O05 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Structure and mechanism of spermidine synthases.
Biochemistry
|