CATH Domain 2nvqA05

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.274	Enzyme I; Chain A, domain 2
	1.10.274.100	RNA polymerase Rpb1, domain 3

Domain Context

CATH Clusters

Superfamily	RNA polymerase Rpb1, domain 3
Functional Family	DNA-directed RNA polymerase subunit

Enzyme Information

2.7.7.6

DNA-directed RNA polymerase.

based on mapping to UniProt P04050

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P16370

RPB3_YEAST

Saccharomyces cerevisiae S288C

DNA-directed RNA polymerase II subunit RPB3

PDB Structure

PDB	2NVQ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis Wang, D., Bushnell, D.A., Westover, K.D., Kaplan, C.D., Kornberg, R.D. Cell(Cambridge,Mass.)