CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.720 | Transcription Termination Factor Rho, Rna-binding Domain; Chain A, Domain 1 |
|
1.10.720.80 |
Domain Context
CATH Clusters
| Superfamily | 1.10.720.80 |
| Functional Family | Peptidylprolyl isomerase |
Enzyme Information
| 5.2.1.8 |
Peptidylprolyl isomerase.
based on mapping to UniProt Q00688
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.
|
UniProtKB Entries (1)
| Q00688 |
FKBP3_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase FKBP3
|
PDB Structure
| PDB | 2MPH |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Solution Structure of human FK506 binding Protein 25
To be Published
|