CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.505 | SHC Adaptor Protein |
|
3.30.505.10 | SH2 domain |
Domain Context
CATH Clusters
| Superfamily | SH2 domain |
| Functional Family | Vav guanine nucleotide exchange factor 2 |
Enzyme Information
UniProtKB Entries (2)
| P15498 |
VAV_HUMAN
Homo sapiens
Proto-oncogene vav
|
| P48025 |
KSYK_MOUSE
Mus musculus
Tyrosine-protein kinase SYK
|
PDB Structure
| PDB | 2LCT |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Two closely spaced tyrosines regulate NFAT signaling in B cells via Syk association with Vav.
Mol.Cell.Biol.
|
