CATH Domain 2l5sA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.10	Ribbon
	2.10.60	CD59
	2.10.60.10	CD59

Domain Context

CATH Clusters

Superfamily	CD59
Functional Family	Receptor protein serine/threonine kinase

Enzyme Information

2.7.11.30

Receptor protein serine/threonine kinase.

based on mapping to UniProt P36897

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P36897

TGFR1_HUMAN

Homo sapiens

TGF-beta receptor type-1

PDB Structure

PDB	2L5S
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	The TbetaR-I Pre-Helix Extension Is Structurally Ordered in the Unbound Form and Its Flanking Prolines Are Essential for Binding Zuniga, J.E., Ilangovan, U., Mahlawat, P., Hinck, C.S., Huang, T., Groppe, J.C., McEwen, D.G., Hinck, A.P. J.Mol.Biol.