CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.160 | Double Stranded RNA Binding Domain |
|
3.30.160.20 |
Domain Context
CATH Clusters
| Superfamily | 3.30.160.20 |
| Functional Family | double-stranded RNA-specific editase 1 isoform X1 |
Enzyme Information
| 3.5.4.37 |
Double-stranded RNA adenine deaminase.
based on mapping to UniProt Q91ZS8
Adenine in double-stranded RNA + H(2)O = hypoxanthine in double-stranded RNA + NH(3).
-!- This eukaryotic enzyme is involved in RNA editing. -!- It destabilizes double-stranded RNA through conversion of adenosine to inosine. -!- Inositol hexakisphosphate is required for activity.
|
UniProtKB Entries (1)
| Q91ZS8 |
RED1_MOUSE
Mus musculus
Double-stranded RNA-specific editase 1
|
PDB Structure
| PDB | 2L2K |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
The Solution Structure of the ADAR2 dsRBM-RNA Complex Reveals a Sequence-Specific Readout of the Minor Groove.
Cell(Cambridge,Mass.)
|
