CATH Domain 2l2dA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.8	Helicase, Ruva Protein; domain 3
	1.10.8.10	DNA helicase RuvA subunit, C-terminal domain

Domain Context

CATH Clusters

Superfamily	DNA helicase RuvA subunit, C-terminal domain
Functional Family	OTU domain-containing protein 7A

Enzyme Information

3.4.19.12

Ubiquitinyl hydrolase 1.

based on mapping to UniProt Q8TE49

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

Q8TE49

OTU7A_HUMAN

Homo sapiens

OTU domain-containing protein 7A

PDB Structure

PDB	2L2D
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	The amino-terminal UBA domain of OTUD7A Wu, B., Asinas, A., Yee, A., Doherty, R., Lemak, A., Gutmanas, A., Houliston, S., Semesi, A., Arrowsmith, C.H., Montelione, G.T., Dhe-Paganon, S. To be Published

Network disruptions