CATH Domain 2k9yA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.5	Single alpha-helices involved in coiled-coils or other helix-helix interfaces
	1.20.5.510	Single helix bin

Domain Context

CATH Clusters

Superfamily	Single helix bin
Functional Family	Ephrin type-A receptor 2

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P29317

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P29317

EPHA2_HUMAN

Homo sapiens

Ephrin type-A receptor 2

PDB Structure

PDB	2K9Y
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	Left-Handed Dimer of EphA2 Transmembrane Domain: Helix Packing Diversity among Receptor Tyrosine Kinases Bocharov, E.V., Mayzel, M.L., Volynsky, P.E., Mineev, K.S., Tkach, E.N., Ermolyuk, Y.S., Schulga, A.A., Efremov, R.G., Arseniev, A.S. Biophys.J.