CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.640 | Actin; Chain A, domain 4 |
|
3.90.640.80 |
Domain Context
CATH Clusters
| Superfamily | 3.90.640.80 |
| Functional Family |
Enzyme Information
| 2.4.2.- |
Pentosyltransferases.
based on mapping to UniProt P09874
|
| 2.4.2.30 |
NAD(+) ADP-ribosyltransferase.
based on mapping to UniProt P09874
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.
-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.
|
UniProtKB Entries (1)
| P09874 |
PARP1_HUMAN
Homo sapiens
Poly [ADP-ribose] polymerase 1
|
PDB Structure
| PDB | 2JVN |
| External Links | |
| Method | SOLUTION NMR |
| Organism | Escherichia |
| Primary Citation |
Domain C of human poly(ADP-ribose) polymerase-1 is important for enzyme activity and contains a novel zinc-ribbon motif.
Biochemistry
|
