CATH Domain 2i9pB02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1040	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
	1.10.1040.10	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2

Domain Context

CATH Clusters

Superfamily	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Functional Family	3-hydroxyisobutyrate dehydrogenase

Enzyme Information

1.1.1.31

3-hydroxyisobutyrate dehydrogenase.

based on mapping to UniProt P31937

3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH.

UniProtKB Entries (1)

3HIDH_HUMAN

Homo sapiens

3-hydroxyisobutyrate dehydrogenase, mitochondrial

PDB Structure

PDB	2I9P
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of human hydroxyisobutyrate dehydrogenase complexed with NAD+ Kavanagh, K.L., Papagrigoriou, E., Salah, E., Lukacik, P., Smee, C., Burgess, N., von Delft, F., Weigelt, J., Arrowsmith, C., Sundstrom, M., Edwards, A., Oppermann, U. To be Published