CATH Domain 2i4iA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	ATP-dependent RNA helicase DDX3X

Enzyme Information

3.6.4.13

RNA helicase.

based on mapping to UniProt O00571

ATP + H(2)O = ADP + phosphate.

-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

O00571

DDX3X_HUMAN

Homo sapiens

ATP-dependent RNA helicase DDX3X

PDB Structure

PDB	2I4I
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal Structure of Conserved Domains 1 and 2 of the Human DEAD-box Helicase DDX3X in Complex with the Mononucleotide AMP Hogbom, M., Collins, R., van den Berg, S., Jenvert, R.-M., Karlberg, T., Kotenyova, T., Flores, A., Karlsson Hedestam, G.B., Holmberg Schiavone, L.H. J.Mol.Biol.